Assessment of early response to neoadjuvant chemotherapy in multi-site high-grade serous ovarian cancer using hyperpolarized-¹³C MRI.

ABSTRACT:

Background

To evaluate the capability of hyperpolarized [1-¹³C] pyruvate MRI to predict pathologic response to neoadjuvant treatment in multi-site abdominopelvic disease of high-grade serous ovarian cancer (HGSOC) patients and to compare ¹³C MRI and [¹⁸F]-FDG PET/CT measurements for detecting early treatment response. We recruited eight patients with HGSOC in this prospective study who underwent ¹³C MRI and [¹⁸F]-FDG PET/CT before and after the first cycle of neoadjuvant chemotherapy treatment (NACT). Imaging parameters were compared with clinical and histophatologic parameters.

Results

We demonstrate here that ¹³C MRI of hyperpolarized [1-¹³C]pyruvate metabolism in multiple abdominal metastases res

SUBMITTER: Beer L 

PROVIDER: S-EPMC12006644 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature