Neurophysiological signatures of ageing: compensatory and compromised neural mechanisms.

ABSTRACT: Spatiotemporal patterns of neural oscillations change with ageing, even in the cognitively unimpaired individual. Whether these neurophysiological changes represent ageing-related vulnerabilities or mechanisms that support cognitive resilience remains largely unknown. In this study, we used magnetoencephalography imaging to examine age-related changes of resting-state whole-brain neurophysiology in a well-characterized cohort of cognitively unimpaired individuals (n = 70; age range 52-87 years). We quantified spatial patterns of age-related changes in band-limited spectral power within delta-theta (2-7 Hz), alpha (8-12 Hz) and beta (13-30 Hz) bands and the spectral aperiodic slope (15-50 Hz), and examined how spectral changes are associated with cognitive abilities in healthy ageing

SUBMITTER: Ranasinghe KG 

PROVIDER: S-EPMC12006661 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature