Gut microbiota characteristics in neonatal respiratory distress syndrome and the therapeutic potential of probiotics in recovery.

ABSTRACT:

Background

Neonatal Respiratory Distress Syndrome (NRDS) is a common and severe respiratory disorder in neonates, particularly among preterm infants (PTIs), and is often associated with hypoxemia and multiple organ dysfunction. This study aims to investigate the gut microbiota characteristics in NRDS and the potential regulatory role of probiotics in restoring gut microbiota dysbiosis.

Methods

This study enrolled 55 PTIs diagnosed with NRDS and 26 preterm infants without NRDS. The NRDS group was classified into two groups based on treatment: an antibiotic-only group (TA group, N = 30) and an antibiotic plus probiotics group (TB group, N = 25). Fecal samples were collected within 48 h of birth and again after recovery, for 16S rRNA sequencing.

Results

The

SUBMITTER: Fu Y 

PROVIDER: S-EPMC12006762 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature