Long-term characterization of cognitive phenotypes in children with seizures over 36 months.

ABSTRACT:

Rationale

Children with new-onset epilepsies often exhibit co-morbidities including cognitive dysfunction, which adversely affects academic performance. Application of unsupervised machine learning techniques has demonstrated the presence of discrete cognitive phenotypes at or near the time of diagnosis, but there is limited knowledge of their longitudinal trajectories. Here we investigate longitudinally the presence and progression of cognitive phenotypes and academic status in youth with new-onset seizures as sibling controls.

Methods

282 subjects (6-16 years) were recruited within 6 weeks of their first recognized seizure along with 167 unaffected siblings. Each child underwent a comprehensive neuropsychological assessment at baseline, 18 and 36 months later. Factor analy

SUBMITTER: Eisner J 

PROVIDER: S-EPMC12006876 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature