Oncological treatments have limited effects on the fertility prognosis in testicular cancer: A systematic review and meta-analysis.

ABSTRACT:

Background

Testicular cancer is the most common solid tumour among young men in the reproductive phase. After completing cancer treatment, up to 77% of cancer survivors report an interest in paternity after completing cancer treatment. To preserve fertility, most guidelines recommend that physicians should counsel their patients about sperm cryopreservation before initiating gonadotoxic therapy. However, few studies have assessed fertility parameters after testicular cancer therapies over the last 20 years.

Objectives

To close the gap of data regarding gonadotoxicity of testicular cancer therapies to enable more accurate counselling regarding fertility preservation.

Materials and methods

A systematic literature search was conducted in Medline, Embase and Cochrane unti

SUBMITTER: Pape J 

PROVIDER: S-EPMC12006886 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature