Immune regulation and clinical response of Chinese herbal injections combined with TACE in hepatocellular carcinoma: a cumulative logit regression and Bayesian network meta-analysis.

ABSTRACT:

Objectives

This study evaluated the immunomodulatory effects and clinical efficacy of Chinese herbal injections (CHIs) combined with transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients using cumulative logit regression and Bayesian network meta-analysis.

Methods

A systematic review of 48 randomized controlled trials (RCTs) involving 4,293 HCC patients was conducted using PubMed, Cochrane Library, EMBASE, Scopus, and Google Scholar. Outcomes included immune markers (CD3+, CD4+, CD8+, CD4+/CD8+ ratio, and NK cells), clinical response rate, and overall survival (6-month, 1-year, and 2-year). Cumulative logit regression and Bayesian network meta-analysis were applied to synthesize ordinal and continuous outcomes.

Results

Compared to

SUBMITTER: Gu W 

PROVIDER: S-EPMC12006906 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature