White Light Transmission Spectroscopy for Rapid Quality Control Imperfection Identification in Nanoimprinted Surface-Enhanced Raman Spectroscopy Substrates.

ABSTRACT: Miniaturized biomedical sensor development requires improvements in lithographic processes in terms of cost and scalability. Of particular promise is nanoimprint lithography (NIL), but this can suffer from a lack of high-fidelity pattern reproducibility between master and imprinted substrates. Herein, we present a multidisciplinary investigation into gold- and iron-coated NIL sensors including custom optics and spectroscopy, scanning probe microscopy, and data analysis insights. Polyurethane NIL-made nanodome arrays were interrogated with white light transmission spectroscopy, coupled with principal component analysis (PCA) to investigate potential offsets in the photon-substrate plane interaction angle, an imperfection in NIL substrates. Large-angle mismatches (2-10°) were found to be eas

SUBMITTER: Hardy M 

PROVIDER: S-EPMC12006957 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature