Regulation of Protein Transport in Functionalized PET Nanopores.

ABSTRACT: Facilitated translocation is a critical mechanism for transporting substances in biological systems, where molecular and ionic species move across the biological membrane with the help of specific transmembrane protein ion channels. In this work, we systematically examined protein transport in three poly(ethylene terephthalate) (PET) nanopores modified with different types of surface functions (hydroxyl, phenyl, and amine). We found that the event signature as well as the kinetics and thermodynamics of protein movement in the PET nanopore varied significantly with the change in the surface function in the pore. In addition to the electrophoretic effect, other factors such as diffusion, electro-osmotic effect, ion selectivity of the channel, and affinity strength between the protein species

SUBMITTER: Kong J 

PROVIDER: S-EPMC12006970 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature