Heterogeneity in pericyte inflammatory responses across age and species highlight the importance of human cell models.

ABSTRACT: Pericytes in the central nervous system are essential for maintaining blood-brain barrier function, regulating blood flow, modulating immune responses, and interacting closely with surrounding cells of the neurovascular unit to support brain homeostasis. Increasing evidence has highlighted their involvement in age-related neuroinflammation, where their dysfunction may contribute to sustained inflammatory states associated with neurodegenerative disorders. Here, we compared inflammatory responses to lipopolysaccharide (LPS) in primary cerebral pericytes from neonatal and adult mice and adult humans. Our findings indicate that neonatal mouse pericytes display heightened inflammatory activation, with elevated levels of ICAM-1 and several cytokines, compared to adult mouse pericytes reflecting

SUBMITTER: Stevenson TJ 

PROVIDER: S-EPMC12007128 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature