Global patterns and burden of soft tissue and extraosseous sarcomas: trends from 1990 to 2021.

ABSTRACT:

Background

Soft tissue sarcomas (STS) are a rare group of malignant tumors originating from soft tissues. The study systematically evaluates the global burden of soft tissue and extraosseous sarcomas from 1990 to 2021 across diverse populations.

Methods

We examined incidence, mortality, and disability-adjusted life years (DALYs) using data from the Global Burden of Disease (GBD) 2021 database. Estimated annual percentage change (EAPC) assessed trends from 1990 to 2021. Cross-country inequality was evaluated using the socio-demographic index (SDI), inequality slope index, and concentration index. Decomposition analysis identified key drivers of changes in disease burden. Frontier analysis pinpointed countries with potential for improvement, while Bayesian age-period-cohort (B

SUBMITTER: Zhu M 

PROVIDER: S-EPMC12007134 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature