Single cell RNA sequencing after moderate traumatic brain injury: effects of therapeutic hypothermia.

ABSTRACT: Traumatic brain injury (TBI) initiates a cascade of cellular and molecular events that promote acute and long-term patterns of neuronal, glial, vascular, and synaptic vulnerability leading to lasting neurological deficits. These complex responses lead to patterns of programmed cell death, diffuse axonal injury, increased blood-brain barrier disruption, neuroinflammation, and reactive gliosis, each a potential target for therapeutic interventions. Posttraumatic therapeutic hypothermia (TH) has been reported to be highly protective after brain and spinal cord injury and studies have investigated molecular mechanisms underlying mild hypothermic protection while commonly assessing heterogenous cell populations. In this study we conducted single-cell RNA sequencing (scRNA-seq) on cerebral corti

SUBMITTER: Kerr NA 

PROVIDER: S-EPMC12007139 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature