Cost-benefit analysis of p16^INK4a immunocytology and liquid-based cytology triage after primary HPV testing for cervical cancer screening in China.

ABSTRACT:

Background

HPV testing has become the recommended primary screening method for cervical cancer in China. However, referring all HPV-positive patients for colposcopy is not practical. This study monetized clinical performance metrics to evaluate the relative performance of 10 secondary triage strategies compared to referring all patients for colposcopy.

Methods

Using real-world HR-HPV sample data and strictly adhering to the HPV-FRAMEWORK, a Markov model was employed to simulate the missed diagnosis losses and health utility losses associated with referring all patients for colposcopy. These losses were monetized using one-time 2023 per capita GDP in China. Incremental net benefits of secondary triage strategies were calculated to identify the optimal strategy. Extensive sens

SUBMITTER: Zhou D 

PROVIDER: S-EPMC12007143 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature