Association between gynecological cancers and female infertility: insights from bidirectional Mendelian randomization analysis.

ABSTRACT:

Purpose

In recent years, research interest in the potential link between female infertility (FI) and gynecological cancer (GC), including ovarian cancer (OC), endometrial cancer (EC), cervical cancer (CC), and breast cancer (BC), has grown, yet findings remain inconclusive. This study aims to explore the causal relationship between FI and GC using bidirectional two-sample Mendelian randomization (MR) analyses, thereby informing future strategies for FI and GC prevention.

Methods

We utilized SNPs identified from genome-wide association studies (GWAS) on FI and GC. The inverse variance weighted (IVW) method served as the primary approach to assess the causal association between FI and GC. Additionally, five other MR methods-Weighted median, Weighted mode, MR-Egger, Simple mode

SUBMITTER: Li J 

PROVIDER: S-EPMC12007144 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature