Malignant mesothelioma-associated inflammatory microenvironment promotes tumor progression via GPNMB.

ABSTRACT:

Background

Tumor-Associated Macrophages (TAMs) are the main immune component of the tumor stroma with heterogeneous functional activities, predominantly suppressing the immune response and promoting tumor progression, also via secretion of different factors. Among these, GPNMB (Glycoprotein non-metastatic B) is usually associated with disease progression in several tumor types. Malignant pleural mesothelioma (MPM) a severe neoplasia with poor prognosis, is characterized by an abundancy of TAMs, testifying the presence of a long-lasting inflammation which is pathogenetic of the disease. However, the role of GPNMB in MPM is unclear.

Methods

Clinical samples from patients with MPM were used to measure RNA and protein levels of GPNMB. The functional role of GPNMB in vivo was stu

SUBMITTER: Belgiovine C 

PROVIDER: S-EPMC12007160 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature