Dynamic evolution and antitumor mechanisms of CXCR6⁺CD8⁺ T cells in small cell lung cancer treated with low-dose radiotherapy and immunotherapy.

ABSTRACT:

Background

Patients with small-cell lung cancer (SCLC) have the poor prognosis. Current research suggested that low-dose radiotherapy (LDRT) combined with immunotherapy can enhance the immunogenicity of tumor cells, thereby improving antigen presentation and promoting the intratumoral infiltration of CD8⁺ T cells, which significantly extends the survival of patients. However, the change trajectory of T cells, and the mechanisms underlying the promotion of intratumoral infiltration of CD8⁺ T cells, and the enhancement of their cytotoxic functions remain to be elucidated.

Methods

To delineate the dynamic changes of T cells, we collected tumors from Kaede tumor-bearing mice that had undergone radioimmunotherapy. Using flow cytometry, we sorted intratumoral

SUBMITTER: Lin G 

PROVIDER: S-EPMC12007177 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature