Exploring the genetic link between gastroesophageal reflux disease and pancreatic cancer: insights from Mendelian randomization.

ABSTRACT:

Background

Gastroesophageal reflux disease (GERD) is increasingly recognized for its associations with extragastric diseases, yet its potential role in pancreatic cancer (PC) etiology remains underexplored. This study investigates the genetic causal relationship between GERD and PC using Mendelian randomization (MR), a method designed to reduce confounding factors.

Methods

A two-sample MR analysis was conducted using genome-wide association studies (GWAS) data. The inverse variance weighted (IVW) method was applied, with additional sensitivity analyses performed to evaluate pleiotropy and heterogeneity.

Results

The IVW analysis demonstrated a significant genetic association between the genetic signature predisposing to GERD and an increased risk of PC (OR: 1.36, 95% C

SUBMITTER: Yang C 

PROVIDER: S-EPMC12007196 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature