Circulating innate lymphoid cells are dysregulated in patients with prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) is the second most common cancer affecting men globally, especially those aged 50 years and above. Despite substantial progress in terms of both prognosis and therapy, PCa remains a significant health concern, necessitating the identification of novel therapeutic targets. Innate lymphoid cells (ILCs) have emerged as critical modulators of tumor immunity, exhibiting both pro- and antitumoral effects. However, little is known yet about their contribution in PCa. This study investigated the phenotypic and functional profiles of ILC subsets in the peripheral blood mononuclear cells (PBMCs) of patients with PCa stratified by Gleason score.

Methods

PBMCs were isolated by Lymphoprep. ILC frequency and activity were evaluated by flow cytometry. The l

SUBMITTER: Maresca DC 

PROVIDER: S-EPMC12007220 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature