Fibrotic pulmonary dust foci is an advanced pneumoconiosis lesion in rats induced by titanium dioxide nanoparticles in a 2-year inhalation study.

ABSTRACT:

Background

We have previously reported that inhalation exposure to titanium dioxide nanoparticles (TiO₂ NPs) for 13 weeks causes early pneumoconiosis lesions in the alveolar region of F344 rats. We defined these characteristic lesions as pulmonary dust foci (PDF). In this report, we re-evaluate and detail the histopathological data regarding particle-induced pneumoconiosis lesions, including progressive lesions of the early PDF lesions, that developed in F344 rats exposed TiO₂ NPs by whole body inhalation over a period of two years.

Methods

Male and female F344 rats were exposed to 0.5, 2, and 8 mg/m³ anatase type TiO₂ NPs for 6 h/day, 5 days/week for 104 weeks using a whole-body inhalation exposure system. After the final exposure

SUBMITTER: Yamano S 

PROVIDER: S-EPMC12007250 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature