The glucose metabolism reprogramming of yak Sertoli cells under hypoxia is regulated by autophagy.

ABSTRACT: Hypoxia often has negative effects on testis development and spermatogenesis of mammals. Plateau yaks have lived in the hypoxia environment for generations, but have ensured testicular function, which is closely related to their unique hypoxia response mechanism. Glucose metabolic reprogramming is an important way for cells to respond to stressful environments, especially the metabolite lactate, which is the energy basis for the development and differentiation of germ cells. In this study, hypoxia (5% O₂) effectively promoted yak Sertoli cell proliferation and decreased autophagy and apoptosis. It was found that the cells showed good hypoxic adaptation. Metabolomics results showed that glucose metabolism was enhanced in yak Sertoli cells in response to hypoxia, and 13 glucose me

SUBMITTER: Ma R 

PROVIDER: S-EPMC12007286 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature