Adjuvant ovarian function suppression in premenopausal women with hormone receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer: a multi-center retrospective study.

ABSTRACT:

Purpose

Based on SOFT and TEXT trials data, a composite recurrence risk score (CR-score) model was developed for early premenopausal women with hormone receptor -positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer using the subgroup treatment effect map (STEPP) method to guide ovarian function suppression (OFS) application. However, the CR-score model has yet to be validate in real-world settings.

Methods

Our study included patients diagnosed between January 1, 2013, and December 31, 2021, from 42 breast centers in China. We utilized restricted cubic splines (RCS) to visualize continuous CR-score and hazard ratios for breast cancer recurrence. After adjusting for confounding factors via propensity score matching (PSM), Kaplan-Meier curves

SUBMITTER: Lian W 

PROVIDER: S-EPMC12007349 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature