Association between estimated glucose disposal rate and future cardiovascular disease risk across glucose metabolism status: a prospective cohort study.

ABSTRACT:

Background

Cardiovascular disease (CVD) remains a major global health challenge, particularly affected by glucose metabolism status. However, the relationship between estimated glucose disposal rate (eGDR) and future CVD risk across different glucose metabolism status remains unclear.

Methods

We analyzed data from the China Health and Retirement Longitudinal Study (2011-2020) of participants aged ≥ 45 years. The eGDR was calculated using waist circumference, hypertension status, and HbA1c levels. CVD events (stroke or cardiac events) were the outcome. Participants were categorized by glucose metabolism status (normoglycemia, prediabetes, diabetes). Cox proportional hazards models and restricted cubic splines were used to assess associations and potential non-linear relations

SUBMITTER: Liang X 

PROVIDER: S-EPMC12007373 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature