Distinct features of three clinical subtypes in 533 patients with primary hypertrophic osteoarthropathy.

ABSTRACT:

Background

Primary hypertrophic osteoarthropathy (PHO) is a rare genetic disorder classified into clinical subtypes and genetic subtypes. Previous clinical studies have primarily focused on case reports and family analyses, largely characterizing the genetic subtypes. However, there remains a long-standing gap in understanding the characteristics of the different clinical subtypes of PHO. This study aimed to determine the distribution of the three clinical subtypes of PHO and compare their clinical characteristics using a large global sample.

Methods

A systematic literature search was conducted in multiple databases to categorize cases into complete form (CO), incomplete form (IN), and fruste form (FR). Statistical analyses were performed to assess clinical differences in a

SUBMITTER: Cai X 

PROVIDER: S-EPMC12007382 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature