Raman investigation of in vivo radiation exposure on melanin in murine hair.

ABSTRACT: Determining the effects of ionizing radiation from unintended exposure in a nuclear event requires the identification of relevant biomarkers and development of methods to retrospectively estimate the absorbed dose. Melanin, a biologically important natural pigment found in hair, shows promise as a biomarker to assess potential radiation exposure. We investigated Raman spectroscopy as a rapid and noninvasive technique to assess changes in melanin from the hair of C57BL/6 mice to gamma radiation between 0 and 4 Gy. Two excitation wavelengths (532 and 785 nm) were employed to probe the melanin response for changes with radiation exposure. Excitation wavelength-dependent variation in Raman features indicates resonance Raman effects, where a 785-nm excitation is more sensitive to the effects of

SUBMITTER: Poonia M 

PROVIDER: S-EPMC12007448 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature