Histological improvements following energy restriction and exercise: The role of insulin resistance in resolution of MASH.

ABSTRACT:

Background & aims

Metabolic dysfunction-associated steatohepatitis (MASH) is one of the most common liver diseases worldwide and is characterized by multi-tissue insulin resistance. The effects of a 10-month energy restriction and exercise intervention on liver histology, anthropometrics, plasma biochemistries, and insulin sensitivity were compared to standard of care (control) to understand mechanisms that support liver health improvements.

Methods

Following medical diagnosis of MASH, individuals were randomized to treatment (n = 16) or control (n = 8). Liver fat (magnetic resonance spectroscopy), 18-hour plasma biochemical measurements, and isotopically labeled hyperinsulinemic-euglycemic clamps were completed pre- and post-intervention. Body composition and cardiorespirat

SUBMITTER: Mucinski JM 

PROVIDER: S-EPMC12007730 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature