Detection of domestication signals through the analysis of the full distribution of fitness effects.

ABSTRACT: Domestication is a process marked by complex interactions between demographic changes and selective pressures, which together shape genetic diversity. While the phenotypic outcomes of domestication are well documented, its genetic basis-particularly the dynamics of selection-remain less well understood. To investigate these dynamics, we performed simulations designed to approximate the demographic history of large domestic mammals. These simulations used selection coefficients as a modeling tool to represent changes in selection pressures, recognizing that such coefficients are abstractions rather than direct representations of biological reality. Specifically, we analyzed site frequency spectra (SFS) under varying distributions of fitness effects (DFE) and proportions of mutations with di

SUBMITTER: Castellano D 

PROVIDER: S-EPMC12007895 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature