Markers of Negative Emotionality in Individuals With Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder: Role of Childhood Trauma.

ABSTRACT: Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are characterized with heightened negative emotionality (NE) and are frequently comorbid. However, little research has investigated NE in individuals with comorbid AUD/PTSD. We compared psychological and biological markers of NE phenotypes, and alcohol-related outcomes between individuals with AUD with and without PTSD, and healthy controls. Additionally, we evaluated whether childhood trauma severity moderated these relationships. Participants [N = 1292; healthy controls (HC): n = 502 (38.9%); AUD only: n = 610 (47.2%), and AUD/PTSD (CMB); n = 180 (13.9%)] enrolled in the National Institute on Alcohol Abuse and Alcoholism Natural History Protocol underwent clinical, biological and behavioural phenotyping that included ps

SUBMITTER: Cullins EC 

PROVIDER: S-EPMC12007917 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature