Silencing PPP2R1A inhibits the progression of gastric cancer cells.

ABSTRACT:

Background

Protein phosphatase 2 regulatory subunit A alpha (PPP2R1A) is the most common scaffold protein in the PP2A complex and has known tumor-suppressive functions. However, its role in gastric cancer (GC) is still unclear. This study aims to elucidate the potential regulatory role of PPP2R1A in the biological functions of GC.

Methods

The mutation status and expression levels of PPP2R1A in GC were assessed through bioinformatics analysis, the correlation between PPP2R1A levels and patient survival rates was examined, and its potential functional network was analyzed. Stable AGS and MGC803 cell lines were set up for overexpressing and silencing PPP2R1A. The effects on cell proliferation, migration, invasion, and apoptosis were assessed through CCK-8 assays, scratch assays

SUBMITTER: Cheng G 

PROVIDER: S-EPMC12008071 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature