Risk factors and clinical significance of neurodegenerative co-pathologies in symptomatic cerebral small vessel disease.

ABSTRACT:

Background

Cerebral small vessel disease (CSVD) often coexists with neurodegenerative pathologies, yet their role remains underexplored. This study aims to determine their prevalence, risk factors, and cognitive effects in patients with deep perforator arteriopathy (DPA) or cerebral amyloid angiopathy (CAA) using the biomarker-based ATN classification.

Methods

In this cross-sectional study 186 patients (median age 75 years, 41% females, 111 with probable CAA, 75 with DPA) underwent MRI for analysis of CSVD severity and etiology, and lumbar puncture for analysis of cerebrospinal fluid amyloid-β 42/40 ratio, phosphorylated-tau, total-tau and neurofilament light. ATN profiles were related to clinical characteristics, MRI markers and cognitive performance in multivariate regress

SUBMITTER: Arndt P 

PROVIDER: S-EPMC12008077 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature