Evaluation of early chemotherapy response by combining static- and dynamic [¹⁸F]FDG-PET with diffusion-weighted MRI in subcutaneous patient-derived endometrial cancer mouse models.

ABSTRACT:

Background

The combination of carboplatin and paclitaxel is the standard chemotherapy for treatment of high-risk and recurrent endometrial cancer. Evaluation of treatment response by diagnostic imaging is routinely carried out months after start of treatment, and is based on changes in tumor size or appearance of new metastases. The aim of this study was to evaluate early chemotherapeutic response in two subcutaneous endometrial cancer mouse models generated from patient-derived organoids using static- and dynamic [¹⁸F]fluorodeoxyglucose ([¹⁸F]FDG) positron emission tomography (PET) and diffusion-weighted (DW) magnetic resonance imaging (MRI). Mice were injected bilaterally with endometrioid endometrial cancer grade 3 (EEC G3), International Federation of Gyna

SUBMITTER: Espedal H 

PROVIDER: S-EPMC12008091 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature