The application of antibiotic-loaded bone cement in preventing periprosthetic joint infection: an umbrella review.

ABSTRACT:

Objectives

The purpose of this study was to provide thorough, understandable and precise evidence for the clinical use of antibiotic-loaded bone cement (ALBC) in preventing periprosthetic joint infection (PJI).

Methods

We evaluated the effectiveness of ALBC in preventing PJI by conducting an umbrella review of existing meta-analysis. Four databases, PubMed/MEDLINE, Cochrane Library, Embase and Web of Science, were searched until May 2024. Two reviewers were reviewers for literature screening, and data were extracted independently. AMSTAR 2 guideline and GRADE were also used for quality evaluation. The clinical outcomes were evaluated for effectiveness by several indicators, including surface infection rate (SIR), deep infection rate (DIR), total infection rate (TIR), unadjus

SUBMITTER: Cao Y 

PROVIDER: S-EPMC12008095 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature