Preclinical PET imaging in epileptogenesis: towards identification of biomarkers and therapeutic targets.

ABSTRACT:

Background

Epilepsy is a neurological disorder that affects a significant portion of the global population. However, its complexity and the lack of biomarkers hinder the study of its etiology, resulting in a lack of effective treatments to slow down or halt disease development, also called epileptogenesis.

Main body

Animal models have proven to be a crucial tool for studying epileptogenesis, many exhibiting cellular, molecular, and functional alterations that resemble those found in human patients. This review examines preclinical studies that have utilized positron emission tomography, a non-invasive neuroimaging technique that has demonstrated correlation with the pathological features and behavioral comorbidities of the disease and a high predictive value for the severity

SUBMITTER: Hernandez-Martin N 

PROVIDER: S-EPMC12008110 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature