PH-responsive nanovesicles capable of remodeling the tumor microenvironment enable activatable near-infrared-II fluorescence image-guided enhanced radiotherapy.

ABSTRACT: Traditional radiotherapy (RT) lacks the precision to distinguish between tumor and normal tissues, leading to inevitable X-ray-induced side effects in patients. Therefore, it is crucial to develop integrated imaging and therapeutic modalities that can reduce side effects on surrounding healthy tissues while enhancing susceptibility to tumor tissues. In this study, we developed a pH-responsive nanodrug (AuNRs-Mn₃O₄-Ag₂S Ve) by self-assembling the second near-infrared (NIR-II, 950-1700 nm) fluorescent probe Ag₂S quantum dots (QDs), multifunctional nanozyme Mn₃O₄ nanoparticles (NPs), and radiosensitizer gold nanorods (AuNRs) into a single nanoplatform via an emulsion process. This nanodrug enables precise tumor localizat

SUBMITTER: Zhao L 

PROVIDER: S-EPMC12008130 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature