Mid-life association between cardiovascular risk factors and cerebral blood flow in a multi-ethnic population.

ABSTRACT:

Background

Cardiovascular (CV) risk factors are associated with cerebrovascular damage and cognitive decline in late-life. However, it is unknown how different ethnic CV risk profiles relate to cerebral haemodynamics in mid-life. We aimed to investigate associations of CV risk factors with cerebral haemodynamics at two timepoints and examine the impact of ethnicity on these measures.

Methods

From the HELIUS study (53.0 years, 44.8 % female), participants of Dutch (n = 236), Moroccan (n = 122), or South-Asian Surinamese (n = 173) descent were included. Cerebral blood flow (CBF) and its spatial coefficient of variation (sCoV, an ASL-label arrival measure of macrovascular efficiency) were obtained in grey (GM) and white matter (WM). CV risk factors were ass

SUBMITTER: Vriend EMC 

PROVIDER: S-EPMC12008139 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature