Treatment of unacceptable bleeding in long-term users of 52-mg levonorgestrel intrauterine device: a prospective observational study.

ABSTRACT:

Background

In the first month after the insertion of the 52-mg levonorgestrel intrauterine device, irregular vaginal bleeding often occurs. In 6% to 18% of 52-mg levonorgestrel intrauterine device users, irregular vaginal bleeding reoccurs or continues for more than 6 months after insertion of the device. This study hypothesized that the addition of estradiol may be beneficial for the regeneration of the endometrium and may consequently decrease irregular bleeding, as these basal vessels might be shielded by the regenerated endometrium.

Objective

This prospective observational study aimed to evaluate the effectiveness of estradiol in treating irregular bleeding in patients who have had a 52-mg levonorgestrel intrauterine device in place for at least 6 months.

Study design

SUBMITTER: van der Heijden PAHH 

PROVIDER: S-EPMC12008142 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature