Effect of Stimulated Salivary Volume on Dysbiosis of the Salivary Microbiome in Children and Young Adults.

ABSTRACT:

Objectives

This study aimed to determine the salivary factors that influence salivary bacterial counts and the microbiome composition in children and young adults.

Methods

This cross-sectional study included 382 patients who visited the dental clinic in Hiroshima University Hospital. All participants underwent a saliva test and were divided into high- and low-bacterial-count groups based on the median bacterial count. Salivary factors and clinical variables, including the total number of teeth and plaque control record, were analyzed to determine their association with salivary bacterial counts. Furthermore, a comprehensive analysis of microbiome diversity and composition was performed using 16S rRNA sequencing.

Results

Univariate and multivariate analyses identified

SUBMITTER: Shintani T 

PROVIDER: S-EPMC12008148 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature