Quantitative Cortex-Based Mapping With Hybrid ¹⁸F-FDG-PET/MR Images in MRI-Negative Epilepsy.

ABSTRACT:

Objectives

Localization of the network underlying drug-resistant focal epilepsy in individuals considering surgical treatment with unremarkable MRI is challenging. Concordance rates of 40%-69% have been reported with FDG-PET image statistical parametric mapping (SPM). We investigated the efficacy of postprocessing specific to cortices by cortex-based mapping (CBM) on hybrid PET/MR images with healthy subjects to localize sites of seizure onset.

Methods

We retrospectively examined the PET/MR images of 42 MRI-negative individuals with drug-resistant focal epilepsy who had surgery and 23 healthy subjects. Visual interpretation of standardized uptake value ratios (SUVRs), voxelwise mapping with a two-sample t-test of SUVRs (t-map, SPM), and the proposed z-transformation of the S

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12008173 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature