A comparison between radiomic biological age and chronological age in estimating kidney function.

ABSTRACT: Accurate kidney function estimation hinges on essential markers of age and body size. The relative benefit of both markers has been debated with the emerging biological age and novel body size descriptors. We used radiomic biomarkers of age-related changes in body composition to construct new biological age indices as covariates of kidney function. A retrospective cohort of hospitalized patients with plasma concentrations of aminoglycosides and computed tomography images were evaluated. Aminoglycoside clearance served as a kidney function surrogate. A population pharmacokinetic model was constructed to determine whether biological age indices improved aminoglycoside clearance estimation compared to chronological age. The final dataset included 156 patients (51.92% female) with a median (mi

SUBMITTER: Alikhani R 

PROVIDER: S-EPMC12008189 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature