The long-term correlates of developmental stress on whole-brain functional connectivity during emotion regulation.

ABSTRACT: Early life stress is associated with alterations in brain function and connectivity during affective processing, especially in the fronto-limbic pathway. However, most of the previous studies were limited to a small set of priori-selected regions and did not address the impact of stress timing on functional connectivity. Using data from a longitudinal birth cohort study (n = 161, 87 females, mean age (SD) = 32.2(0.3)), we investigated the associations between different time points of stress exposure and functional connectivity. We measured stressful life events across development using a modified version of Munich Event List and grouped into four developmental stages: prenatal/newborn (prenatal-3 months), infancy and toddlerhood (3 months-4.5 years), childhood (4.5-11 years), and adolescen

SUBMITTER: Sacu S 

PROVIDER: S-EPMC12008206 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature