SLC25A19 is a key prognostic marker for hepatocellular carcinoma.

ABSTRACT: SLC25A19 is a protein that mediates the transport of thiamine pyrophosphate (TPP) across cell membranes, but its significance in cancer remains largely unknown. To address this knowledge gap, we conducted a pan-cancer analysis to investigate the role of SLC25A19 in cancer. To investigate the role of SLC25A19 in cancer, we obtained RNA-seq, survival, and clinicopathological data from 33 cancers in the TCGA database. We performed expression and survival analyses of SLC25A19 across these cancers. Additionally, we explored the diagnostic and prognostic value of SLC25A19 specifically in hepatocellular carcinoma (HCC). To understand the potential role of SLC25A19 in the immune microenvironment of HCC, we also analyzed its expression in relation to immune checkpoint genes. Then we identified the

SUBMITTER: Chen L 

PROVIDER: S-EPMC12008208 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature