Characterization of zebrafish rod and cone photoresponses.

ABSTRACT: Zebrafish is a popular species widely used in vision research. The zebrafish retina has one rod and four cone subtypes (UV-, blue-, green-, and red-sensitive) with 40%-rod 60%-cone ratio, making it suitable for comparable studies of rods and cones in health and disease. However, the basic photoresponse properties of the four zebrafish cone subtypes have not been described yet. Here, we established a method for collecting flash photoresponses from zebrafish rods and cones by recording membrane current with a suction electrode. Photoreceptor subtypes could be distinguished based on their characteristic morphology and spectral sensitivity. Rods showed 40-220-fold higher photosensitivity than cones. In the four cone subtypes, green-sensitive cones showed the highest sensitivity, 5.5-fold highe

SUBMITTER: Sato S 

PROVIDER: S-EPMC12008237 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature