Assessment of the biocompatibility and biodistribution of fluorescent oleic acid capped ZnSe/CdS/ core shell quantum dots after intravenous injection in Balb/c mice.

ABSTRACT:

Introduction

Quantum dots (QDs) are semiconductor nanocrystals with inherent fluorescence having several advantages over traditional fluorescent probes including their small size (5-10 nm), tunable excitation and emission spectra, ease of surface functionalization, and robust photostability that makes them ideal candidates for in vivo imaging. The behavior of QDs is highly dependent on the surface functionality. In vivo toxicity of QDs in biological systems is the major limitation hindering their translation to clinics.

Methods

In the present study, cytotoxicity of water soluble ZnSe/CdS core shell QDs capped with oleic acid was evaluated against human hepatocellular carcinoma cell line-Hep3B, Human Embryonic Kidney cell line-HEK 293 and Ehlrich Ascitic cells-E

SUBMITTER: Tyagi A 

PROVIDER: S-EPMC12008253 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature