Mendelian randomization study of sleep traits and risk of colorectal cancer.

ABSTRACT: A potential association of endogenous circadian rhythm disruption with risk of cancer development has been suggested, however, epidemiological evidence for the association of sleep traits with colorectal cancer (CRC) is limited and often contradictory. Here we investigated whether genetically predicted chronotype, insomnia and sleep duration are associated with CRC risk in males, females and overall and according to CRC anatomical subsites using Mendelian randomization (MR). The two-sample inverse variance weighted (IVW) method was applied using summary-level data in up to 58,221 CRC cases and 67,694 controls and genome-wide association data of genetic variants for self-reported sleep traits. Secondary analyses using alternative instruments and sensitivity analyses assessing potential viol

SUBMITTER: Dimopoulou O 

PROVIDER: S-EPMC12008275 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature