Effect of in vivo reprogramming of astrocytes combined with exercise training on neurorepair in rats with spinal cord injury.

ABSTRACT:

Background

The inability of damaged neurons to regenerate and of axons to establish new functional connections leads to permanent functional deficits after spinal cord injury (SCI). Although astrocyte reprogramming holds promise for neurorepair in various disease models, it is not sufficient on its own to achieve significant functional recovery.

Methods

A rat SCI model was established using a spinal cord impactor. Seven days postsurgery, adeno-associated virus were injected to overexpress the transcription factors NeuroD1 and Neurogenin-2 (Ngn2) in the spinal cord. The rats were then trained to walk on a weight-supported treadmill for 4 weeks, starting 14 days after modeling. The effects of these interventions on motor and sensory functions, as well as spinal cord tissue rep

SUBMITTER: Talifu Z 

PROVIDER: S-EPMC12008439 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature