FOXK1 promotes hormonally responsive breast carcinogenesis by suppressing apoptosis.

ABSTRACT:

Background

Globally, breast cancer constitutes the predominant malignancy in women. Abnormal regulation of epigenetic factors plays a key role in the development of tumors. Anti-apoptosis is a characteristic of tumor cells. Therefore, exploring and identifying relevant epigenetic factors that regulate the apoptosis of tumor cells is the foundation for clarifying the pathogenesis of tumors and achieving precision antitumor therapy.

Method

This study focused on exploring the epigenetic mechanism of FOXK1 in the development of estrogen receptor-positive (ER⁺) breast cancer. We used overexpressing FLAG-FOXK1 MCF-7 cells to perform silver staining mass spectrometry analysis and conducted Co-IP experiments to verify the interactions. ChIP-seq was conducted on MCF-7 cell

SUBMITTER: Zhao M 

PROVIDER: S-EPMC12008446 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature