Stroke prevention in Hispanic children with sickle cell anemia: the SACRED trial.

ABSTRACT:

Abstract

Sickle cell anemia (SCA) is recognized globally, but little is known about affected Hispanic populations. In partnership with the Dominican Republic, a Hispanic Caribbean island with a large SCA population, a transcranial Doppler (TCD) screening program provided hydroxyurea to children with conditional velocities. Building local capacity, 10 Dominican medical graduates were certified in TCD examinations and trained in hydroxyurea management. The Stroke Avoidance for Children in REpública Dominicana (SACRED) trial enrolled 283 children with average age of 8.7 ± 3.4 years and 130 (46%) females. At initial screening, treatment-naïve children with conditional velocities (170-199 cm/s) were younger (6.6 ± 2.7 vs 8.9 ± 3.4 years; P = .0002) and more anemic (hemoglobin, 7.4 ± 0.8

SUBMITTER: Nieves RM 

PROVIDER: S-EPMC12008516 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature