Targeting All Multiple Magnetic Resonance Imaging Prostate Lesions Does Not Enhance Cancer Detection: Insights from the YAU Prostate Cancer Group.

ABSTRACT:

Background and objective

Although diagnostic efficacy of multiparametric magnetic resonance imaging (MRI) in identifying index lesions (ILs) in prostate cancer (PCa) patients is well established, challenges arise when multiple lesions (MLs) are present. Determination of an optimal biopsy strategy for these patients is crucial. This study aims to assess the risk of detecting PCa and clinically significant PCa (csPCa; International Society of Urological Pathology [ISUP] grade group ≥2) when targeting suspicious MRI MLs in addition to the IL.

Methods

We included 1310 biopsy-naïve patients with only a single MRI lesion (SL) and 621 men with MLs. Patients underwent a subsequent targeted biopsy (TBx) of each lesion, along with a systematic biopsy (SBx). We compared TBx alone versu

SUBMITTER: Zattoni F 

PROVIDER: S-EPMC12008533 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature