Deciphering a cryptic minefield: A guide to <i>Cryptosporidium gp60</i> subtyping.

ABSTRACT: For 25 years, analysis of the gp60 gene has been the cornerstone of Cryptosporidium subtyping, particularly for Cryptosporidium hominis and Cryptosporidium parvum, during population-based and epidemiological studies. This gene, which encodes a 60 kDa glycoprotein, is highly polymorphic with several variable features that make it particularly useful for differentiating within Cryptosporidium species. However, while this variability has proven useful for subtyping, it has on occasion resulted in alternative interpretations, and descriptions of novel and unusual features have been added to the nomenclature system, resulting in inconsistency and confusion. The components of the gp60 gene sequence used in the nomenclature that are discussed here include

SUBMITTER: Robinson G 

PROVIDER: S-EPMC12008548 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature