Characterisation of Multiparametric Magnetic Resonance Imaging of the Prostate in Younger Men with Normal Prostate-specific Antigen Within the PROBASE Study.

ABSTRACT:

Background and objective

Multiparametric magnetic resonance imaging (mpMRI) has emerged as an essential tool for the diagnosis of prostate cancer (PC). However, the right time to start screening for PC is not defined. This study aims to analyse mpMRI in young men at the age of 47-52 yr with normal prostate-specific antigen (PSA) values of ≤3 ng/ml.

Methods

In this prospective analysis, consecutive men undergoing PSA screening with PSA levels below 3 ng/ml were offered mpMRI as part of the PROBASE study. Magnetic resonance imaging (MRI) parameters were assessed, and the findings included changes in T2-weighted (T2w) images, apparent diffusion coefficient (ADC), and dynamic contrast enhancement (DCE). Prostate Imaging Reporting and Data System (PI-RADS) category 4 or 5 would i

SUBMITTER: Al-Monajjed R 

PROVIDER: S-EPMC12008618 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature