Integrated omics reveals the regulatory role of PKCα in Sertoli cell proliferation and apoptosis through the MAPK/ERK signaling pathway in goose testis.

ABSTRACT: Testicular development is essential for reproductive performance in geese, as the testes are the primary organs for sperm production and play a pivotal role in egg-laying physiology. Despite their importance, genes, proteins, and pathways regulating goose testicular development are poorly understood. This study employed integrative transcriptomic and proteomic analysis methods to identify critical regulators of testicular development in geese across three reproductive periods. Additionally, the role of PKCα in Sertoli cell proliferation via the MAPK/ERK pathway was evaluated at the cellular level. A total of 8,921 differentially expressed genes and 1,866 differentially expressed proteins were identified, revealing key pathways such as FOXO, MAPK, PPAR, and Hedgehog that regulate testicular

SUBMITTER: Song Y 

PROVIDER: S-EPMC12008624 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature