Molecular heterogeneity of CD30⁺ peripheral T-cell lymphoma with prognostic significance and therapeutic implications: a retrospective multi-centre study.

ABSTRACT:

Background

Peripheral T-cell lymphoma (PTCL) represents a highly heterogeneous group of non-Hodgkin's lymphomas, often with aggressive biological behaviour. CD30 serves as a pivotal surface antigen in PTCL, however, its biological functions and therapeutic potential warrant further investigation.

Methods

We analysed 415 de novo patients with PTCL including 314 in the training cohort and 101 in the validation cohort across 11 medical centres in China. Genomic and transcriptomic profiles were examined by DNA- and RNA-sequencing in 355 and 169 patients, respectively.

Findings

In both cohorts, CD30⁺ PTCL presented significantly increased frequencies of SETD2, STAT3, and PTPRS mutations. Therefore, three molecular subtypes with distinct biological signatures wer

SUBMITTER: Huo YJ 

PROVIDER: S-EPMC12008646 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature